Who am I?
Although originally from the south of the Netherlands I now live with my family in Groningen. And as hobby, I like to collect fossils and am involved as board member in the geological museum (www.oertijdmuseum.nl).
My group is interested in oxidative enzymes containing various cofactors. Research is aimed at obtaining insight in the enzymology of the transformation of synthetic compounds, and the development of improved biocatalysts for such transformations. We study catalytic mechanisms, kinetic properties, and structure-function relationships in enzymes that can be used for regio- and enantioselective synthesis reactions for preparing fine chemicals. We also investigate enzymes involved in the biodegradation of environmental pollutants. Obtaining new enzymes by genome mining, engineering and high-throughput screening are important parts of this work. Applications are developed in various programs with external partners.
There would be no research without my team. There are highly motivated professionals currently working in my group.
My research interests are manyfold and have expanded over the years.
In 2019 the BiocatNL initiative was started. This aims at having a yearly meeting, at a central location in the Netherlands, for everyone interested in biocatalysis and is supported by the working group Applied Biocatalysis of the Dutch Biotechnology Society (NBV). In 2020, BiocatNL was an online event. We hope that the next meeting will be a physical meeting again, scheduled for autumn 2021.